BSE Department seminar engages with Cellular signalling networks which have a bearing on Cancer & Lung diseases

The department of Biological Sciences & Engineering had the pleasure and privilege of organizing an online seminar with Dr. Ramesh Kumar Krishnan, Senior Postdoctoral Researcher at German Cancer Research Center, Frankfurt am Main, Germany this afternoon. He spoke about "Cellular signalling networks that regulate tumorigenesis, cancer metastasis and epithelial senescence"

Cellular signalling switches are crucial for the functional significance of various physiological and pathological processes. The nuclear factor kappa-B (NF-κB) cascade is one of the critical signalling pathways that is involved in regulating distinct mechanisms including tumorigenesis and cancer metastasis. Inhibitors of nuclear factor kappa-B kinases (IKKs) are key regulators of NF-κB signalling. Research in the last couple of decades revealed diverse novel targets of IKK which exhibit the regulatory roles in NF-κB signalling or other signalling cascades. The seminar focused on the identification of novel targets of IKK and their role in breast cancer growth and metastasis and the role of retinoic acid signalling in the maintenance of healthy airway epithelium.