Seminars

Immunoglobulin light chain amyloidosis (AL) is caused by the aberrant production of
amyloidogenic light chains (LC) that accumulate as amyloid deposits in vital organs.
Distinct LC sequences in each patient yield distinct amyloid structures. Moreover,
different tissue microenvironments may also cause identical protein precursors to
adopt distinct amyloid structures. These reasons have contributed to the current
popular opinion that amyloid fibrils exhibit structural polymorphism. To address the

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