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INDIAN INSTITUTE OF TECHNOLOGY PALAKKAD
Nila Campus, Kanjikode, Palakkad, Kerala - 678623
04923 226 300 (Office) | info@iitpkd.ac.in

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Dr. Sushabhan Sadhukhan
Assistant Professor
, Biological Sciences and Engineering
Chemistry
Sushabhan@iitpkd.ac.in
Research Area: Chemical Biology, Bio-organic Chemistry, Drug Discovery, Metabolomics, Proteomics
View Website
  • Biosketch

    Positions:

    • Assistant Professor
      Department of Chemistry, Indian Institute of Technology Palakkad, India
      Duration: July 2019 - present
    • Assistant Professor
      Discipline of Biosciences & Biomedical Engineering, Indian Institute of Technology Indore, India
      Duration: May 2017 - June 2019
    • Postdoctoral Associate
      Department of Chemistry and Chemical Biology, Cornell University, New York, USA
      Duration: Sept 2012 - April 2017

    Educations:

    • Case Western Reserve University, Cleveland, Ohio, USA
      Ph.D. in Chemistry (2012)
    • Indian Institute of Technology Delhi, New Delhi, India
      M.Sc. in Chemistry (2007)
    • University of Calcutta, West Bengal, India
      B.Sc. in Chemistry (Hons.) (2005)
  • Research

    Chemical Biology

    Bio-orthogonal probe development to investigate different protein post-translational modifications (PTMs) and their functions

     

    Development of Small Molecule Inhibitors

    Design, synthesis and pharmaceutical evaluation of inhibitors for key metabolic and epigenetic enzymes

     

    Metabolomics

    Identifying biomarkers for early detection of disease states. Uncovering the role of metabolism in the regulation of epigenetics

     

    Proteomics

    Protein-protein interaction, identification of key targets of various PTMs, phenotypic screening

  • Teaching

    At Indian Institute of Technology Palakkad (IIT Palakkad)

    • CY 5017: Chemistry of Life (M.Sc. Course; Aug 2020)
    • CY 5013: Synthetic Approaches in Chemistry (M.Sc. Course; Aug 2020)
    • BT 2010: Life Sciences (B.Tech. Course; Aug 2020)
    • CY 1140: Chemistry Lab (B.Tech. Course; Jan 2020)
    • CY 5104: Synthesis, Energetics and Dynamics III (M.Sc. Course; Jan 2020)
    • CY 1010: Thermodynamics, Kinetics, and Organic Reactions (B.Tech. Course; July 2019)
    • BT 2010: Life Sciences (B.Tech. Course; July 2019)

    At Indian Institute of Technology Indore (IIT Indore)

    • BSE 608: Advanced Drug Delivery Systems (Ph.D. Course; Autumn 2017, 2018)
    • BSE 651: Biochemistry Lab (M.Sc. Course; Autumn 2017)
    • BSE 102: Biosciences (B.Tech. Course; Spring 2018, 2019)
    • BSE 615: Principles of Chemical Biology (Ph.D. Course; Autumn 2018)
  • Research Group

    Ph.D. Students

     

    Ms. Karthika K, CSIR-JRF

    M.Sc. (2018-2020) in Chemistry from Govt. Victoria College Palakkad, Kerala

    B.Sc. (2015-2018) in Chemistry from Govt. College Chittur, Kerala  

    Joined: Aug 2022

    Email: 202214002@smail.iitpkd.ac.in

     

    Mr. Vishnu NV, HTRA

    M.Sc. (2019-2021) in Chemistry from the University of Calicut, Kerala

    B.Sc. (2016-2019) in Chemistry from Sri Vyasa NSS College, Vyasagiri, Kerala  

    Joined: Aug 2022

    Email: 202214009@smail.iitpkd.ac.in

     

    Mr. Shabin NC, CSIR-JRF

    M.Sc. (2018-2020) in Chemistry from the University of Calicut, Kerala

    B.Sc. (2015-2018) in Chemistry from Govt. Arts & Science College Meenchantha, Kerala 

    Joined: Aug 2021

    Email: 202114002@smail.iitpkd.ac.in

     

    Ms. Revathy S, CSIR-JRF

    M.Sc. (2015-2017) in Chemistry from Govt. Victoria College Palakkad, Kerala

    B.Sc. (2012-2015) in Chemistry from Govt. Victoria College Palakkad, Kerala 

    Joined: Jan 2020

    Email: 202004003@smail.iitpkd.ac.in

     

    Mr. Satyam Singh, Institute Fellow (Continuing at IIT Indore)

    M.Sc. (2016-2018) in Biotechnology from Madurai Kamaraj University, Madurai

    B.Sc. (2013-2016) in Botany (Hons.) from Banaras Hindu University, Varanasi

    Joined: July 2018

    Email: phd1801171001@iiti.ac.in

     

    Ms. Suchi Chaturvedi, DST-Inspire Fellow (Continuing at IIT Indore)

    M.Sc. (2015-2017) in Biochemistry from Devi Ahilya Vishwavidyalaya, Madhya Pradesh

    B.Sc. (2012-2015) in Biochemistry from Rani Durgavati Vishwavidyalaya, Madhya Pradesh

    Joined: July 2018

    Email: phd1801171002@iiti.ac.in


    Project Assistants

     

    Ms. Irene Shajan

    M.Sc. (2017-2019) in Pharmaceutical Chemistry from Sacred Heart College, Cochin (Mahatma Gandhi University, Kottayam)

    B.Sc. (2014-2017) in Chemistry from Sacred Heart College, Cochin (Mahatma Gandhi University, Kottayam)

    Joined: September 2019

    Email: ireneshajan15@gmail.com

     

    M.Sc. Students (project)

     

    Ms. Chandana Yesudas

    M.Sc. (2018-Cont.) in Biotechnology from Amrita School of Biotechnology, Kollam, Kerala

    B.Sc. (2015-2018) in Biotechnology from the University of Kerala, Kerala

    Joined: Jan 2020

    Email: cychandana@gmail.com

     

    Alumni

     

    From IIT Indore:

    Dr. Debashis Majee, Visiting scientist, April 2019-March 2020

    Ms. Sai Kumari Vechalapu, M.Sc. project student, May 2018-June 2019

    Mr. Indranil De, JRF, October 2017-October 2018

  • Additional Information
    Title
    Selected Journal Publications
    Description

    Liya Thurakkal#, Satyam Singh#, Rajarshi Roy, Parimal Kar, Sushabhan Sadhukhan*, Mintu Porel*. An in-silico study on selected organosulfur compounds as potential drugs for SARS-CoV-2 infection via binding multiple drug targets. Chem. Phys. Lett. 2020, Just accepted. (#Equal contribution) DOI: 10.1016/j.cplett.2020.138193.

    Satyam Singh, Md Fulbabu Sk, Avinash Sonawane, Parimal Kar, Sushabhan Sadhukhan*. Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA‐dependent RNA polymerase (RdRp) inhibition: An in-silico analysis. J. Biomol. Struct. Dyn. 2020, Just accepted. DOI: 10.1080/07391102.2020.1796810. 

    Indranil De, Sushabhan Sadhukhan*. Emerging Roles of DHHC-mediated Protein S-palmitoylation in Physiological and Pathophysiological Context. Euro. J. Cell Biol. 2018, 97, 319-338. Featured on the journal cover page.

    https://www.sciencedirect.com/journal/european-journal-of-cell-biology/vol/97/issue/5

    Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella Nelson, John Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert Weiss, Jason Locasale, Johan Auwerx, and Hening Lin. Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Cardiac Function. Proc. Natl. Acad. Sci. U S A. 2016, 113, 4320-4325. (Highlighted on many science news outlets including Science Daily, EurekAlert!, Medical News Today, Scicasts) 

    Sushabhan Sadhukhan, Guo-Fang Zhang, and Gregory P. Tochtrop. Modular Isotopomer Synthesis of γ-Hydroxybutyric Acid for a Quantitative Analysis of Metabolic Fates. ACS Chem. Biol. 2014, 9, 1706-1711.

    Sushabhan Sadhukhan, Yong Han, Zhicheng Jin, Gregory P. Tochtrop, and Guo-Fang Zhang. Glutathionylated 4-Hydroxyalkenal Enantiomers in Rat Organs and Its Contributions Towards the Disposal of 4-Hydroxynonenal in Rat Liver. Free Rad. Biol. Med. 2014, 70, 78-85.

     

    Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Using Selective Isotopic Labeling to Quantitate Parallel Metabolic Pathways. J. Am. Chem. Soc. 2010, 132, 6309-631.

    Title
    Research Funding
    Description

    Early Career Research (ECR) Award (2019-2022), Ongoing

    Funding Source: DST-SERB, India

    Role: PI

    Amount: 37 lakh

     

    Core Research Grant (CRG) (2020-2023), Ongoing 

    Funding Source: DST-SERB, India

    Role: Co-PI

    Amount: 65 lakh

    Title
    Research & Academic Programs Organized
    Description
    • Conducted a short-term course on “Advanced Biological and Chemical Understanding of Disease Diagnostics and Therapeutics” under Continuing Education Program (CEP) (May 17-19, 2018)
    • Organized a two days international symposium entitled as “Emerging Areas in Biosciences and Biomedical Technologies (eBBT) 2018” at IIT Indore during January 5-6, 2018.
    • Organized a one-day international symposium entitled as “Water: Resources, Challenges & Sustainability (WRCS)” at IIT Indore on March 10, 2018.
    Title
    Honors & Awards
    Description
    • ‘Early Career Research Award’ from the Science and Engineering Research Board (SERB), 2018
    • Postdoc Leadership Certificate, Cornell University, Ithaca, NY, USA, 2016.
    • Outstanding oral presentation at the Meeting in Miniature from American Chemical Society, Cleveland section, Cleveland, OH, USA, 2011.
    • Conference Travel Award from Gordon Research Conference based on excellent poster presentation, Boston, MA, USA, 2011.
    • Second prize in Research Showcase, Case Western Reserve University, Cleveland, OH, USA, 2010.
    • Conference Travel Award from the Division of Biological Chemistry of American Chemical Society, San Francisco, CA, USA, 2010.
    • Endowment Sponsored Mentorship Award, Case Western Reserve University, Cleveland, OH, USA, 2010.
    • Merit-Cum-Means (MCM) Scholarship, Indian Institute of Technology Delhi, India, 2005-07.
    • S. J. Jindal Trust Scholarship, New Delhi, India, 2004.
    Title
    Professional Services
    Description

    Member of Board of Research (BoR) of IIT Palakkad (2019-2020)

    Institute colloquium organizer at IIT Palakkad (2019-2020)

    Biology coordinator for DST-sponsored Vigyan Jyoti Program (May 2018) at IIT Indore

    Member Secretary of IIT Indore-Institutional Committee for Stem Cell Research (2017-2019)

    Reviewer for the following peer-reviewed journals: (i) Scientific Reports, (ii) Proteomics, (iii) ACS Applied Materials & Interfaces, (iv) PLoS One, (v) Cell Communication and Signaling.

    Served as a reviewer for the undergraduate summer funding applications from Support of Undergraduate Research & Creative Endeavors (SOURCE), Case Western Reserve University, Cleveland, OH, USA, 2011.

    Served as a judge for the undergraduate poster presentation in SOURCE Symposium & Poster Session, Case Western Reserve University, Cleveland, OH, USA, 2010.

    Member of American Chemical Society (ACS), 2010-current

    Member of Society of Biological Chemists, India (SBCI), Life member

    Title
    Selected Oral Presentations
    Description

    Understanding the Mechanism of Action of (–)-Epigallocatechin-3-gallate (EGCG), A Major Green Tea Polyphenol. Advances at the Interface of Biology & Chemistry, BARC, Mumbai, India, Nov 1-3, 2019.

    Protein Post-Translational Modifications (PTMs): Small Changes, Big Impact. Mitochondria & Metabolism Network Meeting, IISER Pune, India, November 10-11, 2017.

    Metabolomics-assisted Proteomics Identifies Protein Lysine Succinylation and SIRT5 as Important Regulators of Cardiac Metabolism and Function. 252nd American Chemical Society National Meeting, Philadelphia, PA, USA, August 21, 2016.

    Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Cardiac Function. Cornell University, Ithaca, NY, USA, November 13, 2015.

    Protein modifications: When, how, where and so what? Young Investigator Meeting, Massachusetts Institute of Technology, Boston, MA, USA, October 11, 2015.

    A Modular Isotopomer Synthesis of gamma-Hydroxybutyrate (GHB) Reveals Catabolism via Alpha Oxidation. ACS Meeting in Miniature, Ursuline College, Cleveland, OH, USA, March 16, 2011.

    A Modular Isotopomer Synthesis of gamma-Hydroxybutyrate (GHB) Reveals Catabolism via Alpha Oxidation. Departmental Retreat, Case Western Reserve University, Cleveland, OH, USA, October 30, 2010.

    Metabolism of 4-Hydroxy Acids: Using a Selective Isotope Labeling Strategy. Departmental Retreat, Case Western Reserve University, Cleveland, OH, USA, October 3, 2009.

    Title
    Selected Conference (poster) Presentations
    Description

    Sai K Vechalapu, and Sushabhan Sadhukhan*. Understanding the Mechanism of Action of (–)-Epigallocatechin-3-gallate (EGCG), A Major Green Tea Polyphenol. 1st In-house Symposium on Advances in Biosciences and Bioengineering, Indian Institute of Technology Indore, India, February 23, 2019.

    Satyam Singh, Suchi Chaturvedi, and Sushabhan Sadhukhan*. Chemical Biology of DHHC-mediated Protein S-palmitoylation and Dissecting Its Roles in Breast Cancer. Industry-Academia Conclave 2018 (IAC-2018), Indian Institute of Technology Indore, India, November 20, 2018.

    Sushabhan Sadhukhan, Xiaojing Liu, Ornella Nelson, John Stupinski, Sheng Zhang, Robert Weiss, Jason Locasale, and Hening Lin. Metabolomics-assisted Proteomics Reveals the Function of Lysine Succinylation and SIRT5 in Regulation of β-Oxidation of Long-chain Fatty Acids. 64th American Society for Mass Spectrometry Conference, San Antonio, Texas, USA, June 5-9, 2016.

    Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella D. Nelson, Hening Lin. Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Heart Function. Chemistry Biology Interface Symposium, Cornell University, Ithaca, New York, USA, March 7, 2015.

    Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolomics of Lipid Peroxidation Products Using a Selective Isotope Labeling Strategy. Gordon Research Conferences (Molecular and Cellular Biology of Lipids), Waterville Valley, New Hampshire, USA, July 17-22, 2011.

    Sushabhan Sadhukhan, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of Lipid Peroxidation Products Using a Selective Isotope Labeling Strategy. 42nd National Organic Symposium, Princeton University, New Jersey, USA, June 5-9, 2011.

    Sushabhan Sadhukhan, Guo-Fang Zhang, Tonibelle Gatbonton-Schwager, Henri Brunengraber, and Gregory P Tochtrop. The Metabolism and Signaling of the Lipid Peroxidation Product 4-HNE. American Association for Cancer Research and American Chemical Society Joint Meeting, San Diego, California, USA, January 30-February 2, 2011.

    Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism and Signaling of Lipid Peroxidation Products. Gordon Research Conferences (Bioorganic Chemistry), Andover, New Hampshire, USA, June 13-18, 2010.

    Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of 4-Hydroxyacids and 4-Hydroxynonenal Using a Selective Isotope Labeling Strategy. Research Showcase, Case Western Reserve University, Cleveland, Ohio, USA, April 15, 2010.

    Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of 4-Hydroxyacids and 4-Hydroxynonenal Using a Selective Isotope Labeling Strategy. 239th American Chemical Society National Meeting, San Francisco, California, USA, March 21-25, 2010

  • Publications
    In situ global proteomics profiling of EGCG targets using a cell-permeable and Click-able bioorthogonal probe
    Sahadevan, R., Binoy, A., Vechalapu, S.K., Nanjan, P., Sadhukhan, S.*
    Int. J. Biol. Macromol. 123991 (2023)
    Dansyl appended sequence-defined oligomers for selective ultrasensitive detection of Hg2+ in water, paper strips, living cells and its efficient removal
    Jose, A.#, Sahadevan, R.#, Vijay, M, Sadhukhan, S.*, Porel, M.*
    Sens. Actuators B Chem (2023)
    A novel 4"-alkyl ether derivative of green tea polyphenol EGCG as potent and selective EGFR inhibitor: In-vitro and in-silico studies
    Satyam Singh, Revathy Sahadevan, Rajarshi Roy, Mainak Biswas, Priya Ghosh, Parimal Kar, Avinash Sonawane, Sushabhan Sadhukhan*
    RSC Adv. In press (2022)
    Chemico-biological aspects of (−)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects
    Revathy Sahadevan, Satyam Singh, Anupama Binoy, Sushabhan Sadhukhan*
    Crit. Rev. Food. Nutr. Sci. in press (2022)
    Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer
    Yashira L. Negrón Abril, Irma R. Fernandez, Jun Young Hong, Ying-Ling Chiang, Dennis A. Kutateladze, Qingjie Zhao, Min Yang, Jing Hu, Sushabhan Sadhukhan, Bo Li, Bin He, Brenna Remick, Jessica Jingyi Bai, James Mullmann,.... Hening Lin, Robert S. Weiss.
    Oncogene 40 1644–1658 (2021)
    An in-silico study on selected organosulfur compounds as potential drugs for SARS-CoV-2 infection via binding multiple drug targets
    Liya Thurakkal, Satyam Singh, Rajarshi Roy, Parimal Kar, Sushabhan Sadhukhan*, Mintu Porel*
    Chem. Phys. Lett. 763 138193 (2021)
    Plant-derived natural polyphenols as potential antiviral drugs against SARS-CoV-2 via RNA‐dependent RNA polymerase (RdRp) inhibition: An in-silico analysis
    Satyam Singh, Md Fulbabu Sk, Avinash Sonawane, Parimal Kar, Sushabhan Sadhukhan*
    J. Biomol. Struct. Dyn. 39 (16) 6249-6264 (2021)
    Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-dependent Inhibition, and On-target Anticancer Activities
    Nicole A. Spiegelman, Ian R. Price, Hui Jing, Miao Wang, Min Yang, Ji Cao, Jun Young Hong, Xiaoyu Zhang, Pornpun Aramsangtienchai, Sushabhan Sadhukhan, and Hening Lin.
    ChemMedChem. 13 1890-1894 (2018)
    Emerging Roles of DHHC-mediated Protein S-palmitoylation in Physiological and Pathophysiological Context
    Indranil De, Sushabhan Sadhukhan*
    Euro. J. Cell Biol. 97 319-338 (2018)
    SIRT7 Is an RNA-activated Protein Lysine Deacylase
    Zhen Tong, Miao Wang, Yi Wang, David D. Kim, Jennifer K. Grenier, Ji Cao, Sushabhan Sadhukhan, Quan Hao, and Hening Lin.
    ACS Chem. Biol. 12 300-310 (2017)
    SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context
    Zhen Tong, Yi Wang, Xiaoyu Zhang, David D. Kim, Sushabhan Sadhukhan, Quan Hao, and Hening Lin.
    ACS Chem. Biol. 11 742-747 (2016)
    Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Cardiac Function
    Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella Nelson, John Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert Weiss, Jason Locasale, Johan Auwerx, and Hening Lin.
    Proc. Natl. Acad. Sci. USA. 113 4320-4325 (2016)
    High Resolution Metabolomics With Acyl-CoA Profiling Reveals Widespread Remodeling In Response To Diet
    Xiaojing Liu, Sushabhan Sadhukhan, Shengyi Sun, Gregory R. Wagner, Matthew D. Hirschey, Ling Qi, Hening Lin, and Jason W. Locasale.
    Mol. Cell. Proteomics 14 1489-1500 (2015)
    Identification of a Negative Feedback Loop in Biological Oxidant Formation Regulated by 4-Hydroxy-2-(E)-Nonenal
    Tonibelle N. Gatbonton-Schwager, Sushabhan Sadhukhan, Guo-Fang Zhang, John J. Letterio, and Gregory P. Tochtrop.
    Redox Biol. 2 755-763 (2014)
    Glutathionylated 4-Hydroxy-2-(E)-Alkenal Enantiomers in Rat Organs and Its Contributions Towards the Disposal of 4-Hydroxy-2-(E)-Nonenal in Rat Liver
    Sushabhan Sadhukhan, Yong Han, Zhicheng Jin, Gregory P. Tochtrop, and Guo-Fang Zhang.
    Free Rad. Biol. Med. 70 78-85 (2014)
    Modular Isotopomer Synthesis of γ-Hydroxybutyric Acid for a Quantitative Analysis of Metabolic Fates
    Sushabhan Sadhukhan, Guo-Fang Zhang, and Gregory P. Tochtrop.
    ACS Chem. Biol. 9 1706-1711 (2014)
    Catabolism of 4-Hydroxy-2-(E)-Nonenal via Omega- and Omega-1 Oxidation: Stimulated by Ketogenic Diet
    Zhicheng Jin, Jessica M. Berthiaume, Qingling Li, Fabrice Henry, Zhong Huang, Sushabhan Sadhukhan, Peng Gao, Gregory P. Tochtrop, Michelle A. Puchowicz and Guo-Fang Zhang.
    J. Biol. Chem. 289 32327-32338 (2014)
    4-Hydroxy-2-(E)-nonenal (HNE) Catabolism and Formation of HNE Adducts Are Modulated by β-oxidation of Fatty Acids in the Isolated Rat Heart
    Qingling Li, Sushabhan Sadhukhan, Jessica M. Berthiaume, Rafael A. Ibarra, Hui Tang, Shuang Deng, Eric Hamilton, Laura E. Nagy, Gregory P. Tochtrop, and Guo-Fang Zhang.
    Free Rad. Biol. Med. 58 35-44 (2013)
    Metabolomics Coupled to Mass Isotopomer Analysis as a Strategy for Pathway Discovery: Pyrrolyl and Cyclopentenyl Derivatives of the Pro-Drug of Abuse, Levulinate
    Stephanie R. Harris, Guo-Fang Zhang, Sushabhan Sadhukhan, Hua Wang, Chuan Shi, Michelle A. Puchowicz, Vernon E. Anderson, Robert G. Salomon, Gregory P. Tochtrop, and Henri Brunengraber.
    Chem. Res. Toxicol. 26 213-220 (2013)
    Metabolic Characterization of a Sirt5 Deficient Mouse Model
    Jiujiu Yu, Sushabhan Sadhukhan, Lilia G. Noriega, Norman Moullan, Bin He, Robert S. Weiss, Hening Lin, Kristina Schoonjans, and Johan Auwerx.
    Sci. Rep. 3 2806 (2013)
    Metabolism of gamma-Hydroxybutyrate (GHB) in Perfused Rat Livers and Hearts
    Guo-Fang Zhang, Sushabhan Sadhukhan, Gregory P Tochtrop, and Henri Brunengraber.
    Biochem. J. 444 333-341 (2012)
    Metabolomics, Pathway Regulation and Pathway Discovery
    Guo-Fang Zhang, Sushabhan Sadhukhan, Gregory P. Tochtrop, and Henri Brunengraber.
    J. Biol. Chem. 286 23631-23635 (2011)
    Isotopomer Enrichment Assay for Very Short Chain Fatty Acids and Its Metabolic Applications
    Kristyen Tomcik, Rafael A. Ibarra, Sushabhan Sadhukhan, Yong Han, Gregory P. Tochtrop, and Guo-Fang Zhang.
    Anal. Biochem. 410 110-117 (2011)
    Metabolism of Levulinate in Perfused Rat Livers and Live Rats: Conversion to the Drug of Abuse 4-Hydroxypentanoate
    Stephanie R. Harris, Guo-Fang Zhang, Sushabhan Sadhukhan, Anne M. Murphy, Kristyen A. Tomcik, Edwin J. Vazquez, Vernon E. Anderson, Gregory P. Tochtrop, and Henri Brunengraber.
    J. Biol. Chem. 286 5895-5904 (2011)
    Synthesis and Biological Evaluation of Analogues of a Novel Inhibitor of beta-Amyloid Secretion
    Enakshi Chakrabarti, Subrata Ghosh, Sushabhan Sadhukhan, Lawrence Sayre, Gregory P. Tochtrop, and Jonathan D. Smith.
    J. Med. Chem. 53 5302-5319 (2010)
    Using Selective Isotopic Labeling to Quantitate Parallel Metabolic Pathways
    Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop.
    J. Am. Chem. Soc. 132 6309-6311 (2010)
    Catabolism of 4-Hydroxyacids and 4-Hydroxynonenal via 4-Hydroxy-4-Phosphoacyl-CoAs
    Guo-Fang Zhang, Rajan S. Kombu, Takhar Kasumov, Yong Han, Sushabhan Sadhukhan, Jianye Zhang, Lawrence M. Sayre, Dale Ray, K. Michael Gibson, Vernon A. Anderson, Gregory P. Tochtrop and Henri Brunengraber.
    J. Biol. Chem. 284 33521-33534 (2009)
    The Syntheses and Applications of beta-Benzylmercaptoethylamine Derivatives
    Gregory P. Tochtrop, Sushabhan Sadhukhan, Rik Rani Koner, and Subrata Ghosh.
    Tetrahedron 65 10515-10534 (2009)
    Lipase Catalyzed Synthesis of Benzyl Acetate in Solvent-Free Medium Using Vinyl Acetate As Acyl Donor
    Abir B. Majumder, Bhupender Singh, Debjit Dutta, Sushabhan Sadhukhan, and Munishwar N. Gupta.
    Bioorg. Med. Chem. Lett. 16 4041-4044 (2006)

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