sushabhan

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Dr. Sushabhan Sadhukhan
Assistant Professor
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Biosketch

Positions:

  • Assistant Professor
    Discipline of Chemistry, Indian Institute of Technology Palakkad, India
    Duration: July 2019 - present
  • Assistant Professor
    Discipline of Biosciences & Biomedical Engineering, Indian Institute of Technology Indore, India
    Duration: May 2017 - June 2019
  • Postdoctoral Associate
    Department of Chemistry and Chemical Biology, Cornell University, New York, USA
    Duration: Sept 2012 - April 2017

Educations:

  • Case Western Reserve University, Cleveland, Ohio, USA
    Ph.D. in Chemistry (2012)
  • Indian Institute of Technology Delhi, New Delhi, India
    M.Sc. in Chemistry (2007)
  • University of Calcutta, West Bengal, India
    B.Sc. in Chemistry (Hons.) (2005)
Research

Chemical Biology

Bio-orthogonal probe development to investigate different protein post-translational modifications (PTMs) and their functions

 

Development of Small Molecule Inhibitors

Design, synthesis and pharmaceutical evaluation of inhibitors for key metabolic and epigenetic enzymes

 

Metabolomics

Identifying biomarkers for early detection of disease states. Uncovering the role of metabolism in the regulation of epigenetics

 

Proteomics

Protein-protein interaction, identification of key targets of various PTMs, phenotypic screening

Teaching

At Indian Institute of Technology Palakkad (IIT Palakkad)

  • CY 1010: Thermodynamics, Kinetics, and Organic Reactions (B.Tech. Course; July 2019)
  • BT 2010: Life Sciences (B.Tech. Course; July 2019)

At Indian Institute of Technology Indore (IIT Indore)

  • BSE 608: Advanced Drug Delivery Systems (Ph.D. Course; Autumn 2017, 2018)
  • BSE 651: Biochemistry Lab (M.Sc. Course; Autumn 2017)
  • BSE 102: Biosciences (B.Tech. Course; Spring 2018, 2019)
  • BSE 615: Principles of Chemical Biology (Ph.D. Course; Autumn 2018)
Research Group

Ph.D. Students

 

Mr. Satyam Singh, Institute Fellow (Continuing at IIT Indore)

M.Sc. (2016-2018) in Biotechnology from Madurai Kamaraj University, Madurai

B.Sc. (2013-2016) in Botany (Hons.) from Banaras Hindu University, Varanasi

Joined: July 2018

Email: phd1801171001@iiti.ac.in

 

Ms. Suchi Chaturvedi, DST-Inspire Fellow (Continuing at IIT Indore)

M.Sc. (2015-2017) in Biochemistry from Devi Ahilya Vishwavidyalaya, Madhya Pradesh

B.Sc. (2012-2015) in Biochemistry from Rani Durgavati Vishwavidyalaya, Madhya Pradesh

Joined: July 2018

Email: phd1801171002@iiti.ac.in

 

Visiting Scientists

 

Dr. Debashis Majee (Continuing at IIT Indore)

Postdoctoral research: (2018-2019) University of Texas at San Antonio, USA

Ph.D. (2012-2017) in Chemistry from Indian Institute of Technology Indore, Madhya Pradesh

M.Sc. (2008-2010) in Chemistry from Visva Bharati University, West Bengal

B.Sc. (2005-2008) in Chemistry (Hons.) from Visva Bharati University, West Bengal

Joined: April 2019

Email: debashis@iiti.ac.in

 

Alumni

 

From IIT Indore:

 

Ms. Sai Kumari Vechalapu, M.Sc. student, May 2018-June 2019

Mr. Indranil De, JRF, October 2017-October 2018

Research Area
Chemical Biology, Bio-organic Chemistry, Drug Discovery, Metabolomics, Proteomics
Additional Information
Title
Selected Journal Publications
Description

Indranil De, Sushabhan Sadhukhan*. Emerging Roles of DHHC-mediated Protein S-palmitoylation in Physiological and Pathophysiological Context. Euro. J. Cell Biol. 2018, 97, 319-338. Featured on the journal cover page.

https://www.sciencedirect.com/journal/european-journal-of-cell-biology/vol/97/issue/5

Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella Nelson, John Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert Weiss, Jason Locasale, Johan Auwerx, and Hening Lin. Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Cardiac Function. Proc. Natl. Acad. Sci. U S A. 2016, 113, 4320-4325. (Highlighted on many science news outlets including Science Daily, EurekAlert!, Medical News Today, Scicasts) 

Sushabhan Sadhukhan, Guo-Fang Zhang, and Gregory P. Tochtrop. Modular Isotopomer Synthesis of γ-Hydroxybutyric Acid for a Quantitative Analysis of Metabolic Fates. ACS Chem. Biol. 2014, 9, 1706-1711.

Sushabhan Sadhukhan, Yong Han, Zhicheng Jin, Gregory P. Tochtrop, and Guo-Fang Zhang. Glutathionylated 4-Hydroxyalkenal Enantiomers in Rat Organs and Its Contributions Towards the Disposal of 4-Hydroxynonenal in Rat Liver. Free Rad. Biol. Med. 2014, 70, 78-85.

 

Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Using Selective Isotopic Labeling to Quantitate Parallel Metabolic Pathways. J. Am. Chem. Soc. 2010, 132, 6309-631.

Title
Research Funding
Description

Early Career Research (ECR) Award (2019-2022), Ongoing

Funding Source: DST-SERB, India

Role: PI

Title
Research & Academic Programs Organized
Description
  • Conducted a short-term course on “Advanced Biological and Chemical Understanding of Disease Diagnostics and Therapeutics” under Continuing Education Program (CEP) (May 17-19, 2018)
  • Organized a two days international symposium entitled as “Emerging Areas in Biosciences and Biomedical Technologies (eBBT) 2018” at IIT Indore during January 5-6, 2018.
  • Organized a one-day international symposium entitled as “Water: Resources, Challenges & Sustainability (WRCS)” at IIT Indore on March 10, 2018.
Title
Honors & Awards
Description
  • ‘Early Career Research Award’ from the Science and Engineering Research Board (SERB), 2018
  • Postdoc Leadership Certificate, Cornell University, Ithaca, NY, USA, 2016.
  • Outstanding oral presentation at the Meeting in Miniature from American Chemical Society, Cleveland section, Cleveland, OH, USA, 2011.
  • Conference Travel Award from Gordon Research Conference based on excellent poster presentation, Boston, MA, USA, 2011.
  • Second prize in Research Showcase, Case Western Reserve University, Cleveland, OH, USA, 2010.
  • Conference Travel Award from the Division of Biological Chemistry of American Chemical Society, San Francisco, CA, USA, 2010.
  • Endowment Sponsored Mentorship Award, Case Western Reserve University, Cleveland, OH, USA, 2010.
  • Merit-Cum-Means (MCM) Scholarship, Indian Institute of Technology Delhi, India, 2005-07.
  • S. J. Jindal Trust Scholarship, New Delhi, India, 2004.
Title
Professional Services
Description
  • Member Secretary of IIT Indore-Institutional Committee for Stem Cell Research (2017-2019)
  • Biology coordinator for DST-sponsored Vigyan Jyoti Program (May 2018) at IIT Indore
  • Reviewer for the following peer-reviewed journals: (i) Scientific Reports, (ii) Proteomics, (iii) ACS Applied Materials & Interfaces, (iv) PLoS One, (v) Cell Communication and Signaling.
  • Served as a reviewer for the undergraduate summer funding applications from Support of Undergraduate Research & Creative Endeavors (SOURCE), Case Western Reserve University, Cleveland, OH, USA, 2011.
  • Served as a judge for the undergraduate poster presentation in SOURCE Symposium & Poster Session, Case Western Reserve University, Cleveland, OH, USA, 2010.
  • Member of American Chemical Society (ACS), 2010-current
  • Member of Society of Biological Chemists, India (SBCI), Life member 
Title
Selected Oral Presentations
Description

Protein Post-Translational Modifications (PTMs): Small Changes, Big Impact. Mitochondria & Metabolism Network Meeting, IISER Pune, India, November 10-11, 2017.

Metabolomics-assisted Proteomics Identifies Protein Lysine Succinylation and SIRT5 as Important Regulators of Cardiac Metabolism and Function. 252nd American Chemical Society National Meeting, Philadelphia, PA, USA, August 21, 2016.

Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Cardiac Function. Cornell University, Ithaca, NY, USA, November 13, 2015.

Protein modifications: When, how, where and so what? Young Investigator Meeting, Massachusetts Institute of Technology, Boston, MA, USA, October 11, 2015.

A Modular Isotopomer Synthesis of gamma-Hydroxybutyrate (GHB) Reveals Catabolism via Alpha Oxidation. ACS Meeting in Miniature, Ursuline College, Cleveland, OH, USA, March 16, 2011.

A Modular Isotopomer Synthesis of gamma-Hydroxybutyrate (GHB) Reveals Catabolism via Alpha Oxidation. Departmental Retreat, Case Western Reserve University, Cleveland, OH, USA, October 30, 2010.

Metabolism of 4-Hydroxy Acids: Using a Selective Isotope Labeling Strategy. Departmental Retreat, Case Western Reserve University, Cleveland, OH, USA, October 3, 2009.

Title
Selected Conference (poster) Presentations
Description

Sai K Vechalapu, and Sushabhan Sadhukhan*. Understanding the Mechanism of Action of (–)-Epigallocatechin-3-gallate (EGCG), A Major Green Tea Polyphenol. 1st In-house Symposium on Advances in Biosciences and Bioengineering, Indian Institute of Technology Indore, India, February 23, 2019.

Satyam Singh, Suchi Chaturvedi, and Sushabhan Sadhukhan*. Chemical Biology of DHHC-mediated Protein S-palmitoylation and Dissecting Its Roles in Breast Cancer. Industry-Academia Conclave 2018 (IAC-2018), Indian Institute of Technology Indore, India, November 20, 2018.

Sushabhan Sadhukhan, Xiaojing Liu, Ornella Nelson, John Stupinski, Sheng Zhang, Robert Weiss, Jason Locasale, and Hening Lin. Metabolomics-assisted Proteomics Reveals the Function of Lysine Succinylation and SIRT5 in Regulation of β-Oxidation of Long-chain Fatty Acids. 64th American Society for Mass Spectrometry Conference, San Antonio, Texas, USA, June 5-9, 2016.

Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella D. Nelson, Hening Lin. Metabolomics-assisted Proteomics Identifies Succinylation and SIRT5 as Important Regulators of Heart Function. Chemistry Biology Interface Symposium, Cornell University, Ithaca, New York, USA, March 7, 2015.

Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolomics of Lipid Peroxidation Products Using a Selective Isotope Labeling Strategy. Gordon Research Conferences (Molecular and Cellular Biology of Lipids), Waterville Valley, New Hampshire, USA, July 17-22, 2011.

Sushabhan Sadhukhan, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of Lipid Peroxidation Products Using a Selective Isotope Labeling Strategy. 42nd National Organic Symposium, Princeton University, New Jersey, USA, June 5-9, 2011.

Sushabhan Sadhukhan, Guo-Fang Zhang, Tonibelle Gatbonton-Schwager, Henri Brunengraber, and Gregory P Tochtrop. The Metabolism and Signaling of the Lipid Peroxidation Product 4-HNE. American Association for Cancer Research and American Chemical Society Joint Meeting, San Diego, California, USA, January 30-February 2, 2011.

Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism and Signaling of Lipid Peroxidation Products. Gordon Research Conferences (Bioorganic Chemistry), Andover, New Hampshire, USA, June 13-18, 2010.

Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of 4-Hydroxyacids and 4-Hydroxynonenal Using a Selective Isotope Labeling Strategy. Research Showcase, Case Western Reserve University, Cleveland, Ohio, USA, April 15, 2010.

Sushabhan Sadhukhan, Yong Han, Guo-Fang Zhang, Henri Brunengraber, and Gregory P Tochtrop. Metabolism of 4-Hydroxyacids and 4-Hydroxynonenal Using a Selective Isotope Labeling Strategy. 239th American Chemical Society National Meeting, San Francisco, California, USA, March 21-25, 2010

Recent Publications

Nicole A. Spiegelman, Ian R. Price, Hui Jing, Miao Wang, Min Yang, Ji Cao, Jun Young Hong, Xiaoyu Zhang, Pornpun Aramsangtienchai, Sushabhan Sadhukhan, and Hening Lin.
ChemMedChem. 13 1890-1894 (2018)
Indranil De, Sushabhan Sadhukhan*
Euro. J. Cell Biol. 97 319-338 (2018)
Zhen Tong, Miao Wang, Yi Wang, David D. Kim, Jennifer K. Grenier, Ji Cao, Sushabhan Sadhukhan, Quan Hao, and Hening Lin.
ACS Chem. Biol. 12 300-310 (2017)
Zhen Tong, Yi Wang, Xiaoyu Zhang, David D. Kim, Sushabhan Sadhukhan, Quan Hao, and Hening Lin.
ACS Chem. Biol. 11 742-747 (2016)
Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella Nelson, John Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert Weiss, Jason Locasale, Johan Auwerx, and Hening Lin.
Proc. Natl. Acad. Sci. USA. 113 4320-4325 (2016)