rosithak | IIT Palakkad

Biosketch

Assistant Professor - IIT Palakkad : June 2021 - Present

Research Experience

University of Pittsburgh, USA (Advisor: Prof. Peng Liu) : Nov. 2020 - June 2021

Georg-August Universität Göttingen, Germany (Advisor: Prof. Lutz Ackermann) : June 2018 - Oct. 2020

Education

PhD - Institut Català d'Investigació Química (ICIQ), Barcelona Institute of Science and Technology (BIST), Spain (Advisor: Prof. Feliu Maseras) : 2013 - 2017

EU-COST International Shortstay - Heriot-Watt University, Scotland, UK (Advisor: Prof. Stuart Macgregor) : 2015

MSc in Chemistry - IIT Bombay, India (Advisor: Prof. R. B. Sunoj) : 2011 - 2013
Research

Mechanistic understanding of the catalytic reaction has been an important and active field of research in computational organic chemistry. The quantum mechanical understanding of catalytic reactions enable us to design new catalyst and predict new reaction mechanisms. Currently, in silico catalyst design is of great interest in generating the key structural motifs in highly demanding natural products and pharmacophores. We employ state of the art computational techniques of quantum mechanics and molecular mechanics to gather an electronic level understanding of the inherent mechanistic details of various reactions ranging from small molecule activation, asymmetric catalysis, bio mimetic reactions, C-H activation, etc. These findings will drive our way to design novel organo- and transition metal catalytic systems and artificial metalloenzymes, which aligns with our environmentally benign and economically attractive research motto for the generation of molecules of our interest.
Teaching

CY5015 - Atomic and Molecular Structure (2021, 2022)

CY1140 - BTech Chemistry Lab

CY1021 - Theoretical and Inorganic Chemistry

CY1040 - BTech Chemistry Lab

CY1040 - Basic Chemistry for Engineers
Research Group

Dr. Surya K - Research Assistant (PhD from IIT Bombay)

Abra Mathew - PhD ( MSc from MG University)

Krishnapriya A. U - PhD (MSc from Central University Tamilnadu)

Dheeraj Kumar - Project Student (IIT Palakkad)

Megha S - Project Student (IIT Palakkad)

Alumni

Munaifa Arif - MSc Project Student (CUSAT)

Mis Ab V. P - Internship Student (IIT Palakkad)

Shubham Gupta - MSc Project Student (IIT Palakkad)

Shahma P K - Internship Student (IISER Tirupati)

Vijay Mahajan - Internship Student (ICT, Mumbai)

Athul S. B - Research Assistant (IISER-TVM)

Majma K - Summer Intern (IISER - TVM)

Jibin Thomas - Summer Intern (IISER - TVM)

Nikhil Mondal - MSc Student (IIT Palakkad)

Sujoy Kumar Sarkar - MSc Student (IIT Palakkad)

Basila Hassan - MSc Project Student (Farook College)

Aleena Raihan - MSc Project Student (Farook College)

Vidya Viswanath - MSc Project Student (MG University)
Additional Information

Title

Funding

Description

Institute Seed Grant

DST-SERB Start-up Research Grant (SRG) 2022

MHRD - Scheme for Transformational and Advanced Research in Sciences (STARS) Grant 2023
Publications

Selective Synthesis of Functionalized Linear Aliphatic Primary Amines via Decarboxylative Radical Polar Crossover Process
Cauwenbergh, R.; Sahoo, P.; Maity, R.; Matthew, A.; Kuniyil, R.; Das, S.*
Green Chem. (2023)

Redox-Neutral Decarboxylative Cross-Coupling of Oxamates with Arylbromides
Bisoy. A.; Simhadri, V.; Surya, K.; Kuniyil, R.;* Yatham, V. R.*
ACS Org Inorg Au. (2023)

Redox-Neutral Radical Cascade Cyclization of N-Arylacrylamides with Unactivated Alkyl and Aryl Chlorides
Jha, A. K.; Nair, D. P.; Munaifa, A.; Yedase, G.; Kuniyil, R.;* Yatham, V. R.*
J. Org. Chem (2023)

Copper(I)-Catalyzed Decarboxylative N-Phosphorylation: Modular Preparation of N-Acyl Iminophosphoranes Using Dioxazolones and Phosphines
Park, J.;' Krishnapriya, A. U.;' Park, Y.; Kim, M.; Reidl, T. W.; Kuniyil, R.;* Son, J.* ('Authors contributed equally)
Adv. Synth. Catal. 2023 (2023)

Amine-rich Nickel(II)-Xerogel as a Highly Active Bifunctional Metallo-organo Catalyst for Aqueous Knoevenagel Condensation and Solvent-free CO2 Cycloaddition
Saha, E.; Jungi, H.; Dabas, S.; Mathew, A.; Kuniyil, R.;* Subramanian, S.;* Mitra, J.*
Inorg. Chem (2023)

Photocatalytic Hydro Tri/Difluoromethylation of Alkenes with Bench Stable Tri/Difluoro Methylating Reagents
Girish, Y.; Munaifa, A.; Kuniyil, R.;* Yatham, V. R.*
Org. Lett. (2023)

Dynamic Kinetic Stereoselective Glycosylation via Rh(II) and Chiral Phosphoric Acid-Cocatalyzed Carbenoid Insertion to Anomeric OH Bond for the Synthesis of Glycoconjugates
Wu, J.; Jia, P.; Kuniyil, R.; Liu, P.; Tang, W.
Angew. Chem. Int. Ed (2023)

Ruthenium-Catalyzed Selective α-Alkylation of β-Naphthols using Primary Alcohols: Elucidating the Influence of Base and Water
Sankar, R. V.; Mathew, A.; Pradhan, S.; Kuniyil, R.;* Gunanathan, C.*
Chem. Eur. J. (2023)

Generation of Photoinduced Phenalenyl-Based Radical: Towards Designing Reductive C-C Coupling Catalysis
Datta, P.; Goswami, T.; Kandoth, N.; Banik, A.; Ahmed, J.; Bhaskaran, A. S.; Saha, R.; Kuniyil, R.; Ghosh, H. N.; Mandal, S. K
ChemPhotoChem (2023)

Reduced-Phenalenyl-Based Molecule as a Super Electron Donor for Radical-Mediated C–N Coupling Catalysis at Room Temperature
Sil, S.; Bhaskaran, A. S.; Chakraborty, S.; Singh, B.; Kuniyil, R.;* Mandal, S. K*
J. Am. Chem. Soc. 2022 144 22611–22621 (2022)

Understanding the unique reactivity patterns of nickel/JoSPOphos manifold in the nickel-catalyzed enantioselective C–H cyclization of imidazoles
Liu, J. B.; Wang, X.; Messinis, A. M.; Liu, X. J.; Kuniyil, R.; Chen, D. Z.; Ackermann, L.
Chem. Sci. 12 718-729 (2021)

Rhodaelectro-catalyzed chemo-divergent C–H activations with alkylidene cyclopropanes for selective cyclopropylations
Shen, Z.; Maksso, I.; Kuniyil, R.; Rogge, T.; Ackermann, L.
Chem. Commun. 57 3668-3671 (2021)

Electrocatalytic C–H phosphorylation through nickel (III/IV/II) catalysis
Zhang, S. K; Vecchio, A. D.; Kuniyil, R.; Messinis, A. M.; Lin, Z.; Ackermann, L.
Chem 7 1379-1392 (2021)

Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2-and C3-Borylated Indolines
Trammel G. R.; Kuniyil, R.; Crook. P. F.; Liu. P.; Brown, M. K.
J. Am. Chem. Soc. 143 16502–16511 (2021)

Recyclable Ruthenium Catalyst for Distal meta-C–H Activation
Choi, I.; Müller, V.; Wang, Y.; Xue, K.; Kuniyil, R.; Andreas, L. B.; Karius, V.; Alauzun, J. G.; Ackermann, L.
Chem. Eur. J. 26 15290 (2020)

Electrochemical B–H Nitrogenation: Access to Amino Acid and BODIPY-Labeled nido-Carboranes
Yang, L.; Jei, B. B.; Scheremetjew, A.; Kuniyil, R.; Ackermann, L.
Angew. Chem. Int. Ed. 60 1482-1487 (2020)

Catalyst-Free, Direct Electrochemical Synthesis of Annulated Medium-Sized Lactams through C‒C Bond Cleavage
Xu, Z.; Huang, Z.; Li, Y.; Kuniyil, R.; Zhang, C.; Ackermann, L.; Ruan, Z.
Green Chem. 22 1099-1104 (2020)

Late-Stage Diversification by Selectivity Switch in meta-C–H Activation: Evidence for Singlet Stabilization
Massignan, L.; Tan, X.; Meyer, T. H.; Kuniyil, R.; Messinis, A. M.; Ackermann, L.
Angew. Chem. Int. Ed. 59 3184-3189 (2020)

C−H Oxygenation Reactions Enabled by Dual Catalysis with Electrogenerated Hypervalent Iodine Species and Ruthenium Complexes
Massignan, L.; Tan, X.; Meyer, T. H.; Kuniyil, R.; Messinis, A. M.; Ackermann, L.
Angew. Chem. Int. Ed. (59) 3184-3189 (2020)

Domino C–H Activation/Directing Group Migration/Alkyne Annulation: Unique Selectivity by d6-Cobalt(III) Catalysts
Zhu, C.; Kuniyil, R.; Jei, B. B.; Ackermann, L.
ACS Catal. 10 4444-4450 (2020)

Regioselective B(3,4)–H Arylation of o-Carboranes by Weak Amide Coordination at Room Temperature
Liang, Y.-F.; Yang, L.; Jei, B. B.; Kuniyil, R.; Ackermann, L.
Chem. Sci. 11 10764-10769 (2020)

Aza-Ruthena(II)-Bicyclo- [3.2.0]-Heptadiene: Key Intermediate for Ruthenaelectro(II/III/I)-Catalyzed Alkyne Annulations
Yang, L.; Steinbock, R.; Scheremetjew, A.; Kuniyil, R.; Finger, L. H.; Messinis, A.; Ackermann, L.
Angew. Chem. Int. Ed. 59 11130-11135 (2020)

Insights into Ruthenium(II/IV)-Catalyzed Distal C–H Oxygenation by Weak Coordination
Bu, Q.; Kuniyil, R.; Zhigao, S.; Gońka, E.; Ackermann, L.
Chem. Eur. J. (26) 16450 (2020)

Photo-Induced Ruthenium-Catalyzed C–H Arylations at Room Temperature
Korvorapun, K.; Struwe, J.; Kuniyil, R.; Zangarelli, A.; Casnati, A.; Waeterschoot, M.; Ackermann, L.
Angew. Chem. Int. Ed. 59 18103-18109 (2020)

Reactivity-Controlling Factors in Carboxylate-Assisted C–H Activation under 4d and 3d Transition Metal Catalysis
Rogge, T.; Oliveira, J.; Kuniyil, R.; Hu, L.; Ackermann, L.
ACS Catal. 10 10551-10558 (2020)

Peptide Late-Stage Diversifications by Rhodium-Catalyzed Tryptophan C7 Amidation
Wang, W.; Wu, J.; Kuniyil, R.; Lima, R. N.; Ackermann, L.
Chem. 6 3428-3439 (2020)

Late-Stage Peptide Diversification by Cobalt-Catalyzed C– H Activation: Sequential Multicatalysis for Stapled Peptides
Lorion, M. M.; Kaplaneris, N.; Son, J.; Kuniyil, R.; Ackermann, L.
Angew. Chem. Int. Ed. 58 1684-1702 (2019)

Manganese(I)-Catalyzed C–H Activation/Diels-Alder/retro-Diels-Alder Domino Alkyne Annulation by Transformable Pyridines
Zhu, C.; Kuniyil, R.; Ackermann, L.
Angew. Chem. Int. Ed. 58 5338-5342 (2019)

BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging
Virelli, M.; Wang, W.; Kuniyil, R.; Wu, J.; Zanoni, G.; Fernandez, A.; Scott, J.; Vendrel, M.; Ackermann, L.
Chem. Eur. J. 25 12712-12718 (2019)

Flow Rhodaelectro-Catalyzed Alkyne Annulations by Versatile C−H Activation: Mechanistic Support for Rhodium(III/IV)
Kong, W.-J.; Finger, L. H.; Messinis, A. M.; Kuniyil, R.; Oliveira, J. C. A.; Ackermann, L.
J. Am. Chem. Soc. 141 17198-17206 (2019)

π-Extended Polyaromatic Hydrocarbons by Sustainable Alkyne Annulations through Double C–H/N–H Activation
Gońka, E.; Yang, L.; Steinbock, R; Pescaioli, F.; Kuniyil, R.; Ackermann, L.
Chem. Eur. J. 25 16246-16250 (2019)

Domino Process toward Functionally Dense Quaternary Carbons through Pd-Catalyzed Decarboxylative C(sp3)–C(sp3) Bond Formation
Guo, W.; Kuniyil, R.; Gómez, J. E.; Maseras, F.; Kleij, A. W. A
J. Am. Chem. Soc. 140 3981-3987 (2018)

Benzoate cyclometalation enables oxidative addition of haloarenes at a Ru (II) center
Simonetti, M.; Kuniyil, R.; Macgregor, S.; Larrosa, I
J. Am. Chem. Soc. 140 11836-11847 (2018)

Rutheniumcatalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents
Dias, G. G.; Rogge, T.; Kuniyil, R.; Jacob, C.; Menna-Barreto, R. F. S.; da Silva Júnior, E. N.; Ackermann, L.
Chem. Commun. 54 12840-12843 (2018)

Computational study on the mechanism of the reaction of carbon dioxide with siloxy silanes
Kuniyil, R.; Maseras, F.
Theor. Chem. Acc. 136 1-7 (2017)

Stereoselective and Versatile Preparation of Tri-and Tetrasubstituted Allylic Amine Scaffolds under Mild Conditions
Guo, W.; Rodríguez, L. M.; Kuniyil, R.; Martin, E.; Adan, E. C. E.; Maseras, F.; Kleij, A. W.
J. Am. Chem. Soc. 138 11970-11978 (2016)

N-Heterocyclic Carbene Catalyzed Asymmetric Intermolecular Stetter Reaction: Origin of Enantioselectivity and Role of Counterions
Kuniyil, R.; Sunoj, R. B.
Org. Lett. 15 5040-5043 (2013)